ea0014oc5.3 | Thyroid basic | ECE2007
Dohan Orsolya
, Portulano Carla
, Ginter Chris
, Carrasco Nancy
The Na+/I− symporter (NIS), a glycoprotein expressed at the basolateral plasma membrane of thyroid epithelial cells, mediates active I− uptake for the biosynthesis of thyroid hormones and radioiodide transport for diagnosis and treatment in thyroid cancer. Our cloning of the NIS cDNA and generation of anti-NIS antibodies provided the basis to investigate the decrease in I− transport in thyroid cancer relative to hea...